WebCD303, also known as BDCA-2 and CLEC4C, is a 38 kD type II transmembrane glycoprotein. It is a member of the C-type lectin superfamily. CD303 is expressed by plasmacytoid dendritic cells (pDCs) and is involved in cell adhesion, signaling, and antigen capture and processing. Crosslinking of CD303 inhibits the production of IFN-α/β and … WebTwo-color flow cytometric analysis of BDCA-2 (CD303) expression on human peripheral blood mononuclear cells. Human peripheral blood mononuclear cells were stained with APC Mouse Anti-Human CD123 (Cat. No. 560087) and either BD Horizon™ BV421 Mouse IgG2b, κ Isotype Control (Cat. No. 562748; Left Panel) or BD Horizon BV421 Mouse Anti-Human ...
Monoclonal antibody targeting BDCA2 ameliorates skin lesions in ...
WebHere we investigated the cross-talk between BDCA-2 and TLR-9-signaling during PDC maturation and antigen presentation. We found that BDCA-2-induced signaling in PDCs inhibits up-regulation of CD86 and CD40 molecules in CpG-activated PDCs, but not in CD40L-activated PDCs. WebDec 17, 2001 · Anti-BDCA-2 monoclonal antibodies are rapidly internalized and efficiently presented to T cells, indicating that BDCA-2 could play a role in ligand internalization and … essential living union wharf
CD141/BDCA-3 Antibodies - Beckman Coulter Life Sciences
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