WebJan 8, 2015 · BTG3 (B-cell translocation gene 3) is a p53 target that also binds and inhibits E2F1. Although it connects two major growth-regulatory pathways functionally and is … WebSep 20, 2014 · BTG3 overexpression up- regulated the protein expression of Cyclin E, p16, p27, NF-κB, p38α/β, XIAP, Bcl-2, ATG14 and p53, but down-regulated the mRNA expression of MRP1, BCRP, and mTOR in ...

Frontiers The clinicopathological significances and related signal ...

WebB-cell translocation gene 3 (BTG3), recognized as a member of an antiproliferative B-cell translocation gene/ Transducer of ErbB2 (BTG/Tob) gene family, is a downstream target of p53 and is induced upon … Webp53. Target Genes. Recent genome-wide analyses and meta-analyses of genome-wide datasets of p53 DNA-binding and gene regulation show that p53 is a direct activator of a limited number of genes compared to the number of putative response-elements identified genome-wide. They also provide evidence that p53 is not a direct repressor of genes . flagship ocean city

Candidate tumor suppressor B-cell translocation gene 3 impedes ...

WebNov 18, 2014 · When DNA is damaged, p53 is upregulated, which will induce DNA repair and cause the cell cycle arrest at G1/S-phase. If damage cannot be repaired, p53 will induce programmed cell death or apoptosis. It has been demonstrated that BTG2 exerts its antitumor effect through p53-dependent Ras signal transduction pathway . Thus, the … WebJan 27, 2016 · p53 deficiency leads to increased growth at metastatic sites. Tumor-bearing mice were monitored for signs of declining health and euthanized when they exhibited … WebGal-3 is down-regulated by wt-p53 and this repression is required for p53-induced apoptosis. Since poorly differentiated thyroid carcinomas (PDTCs) and anaplastic thyroid … flagship ocean city md hotel