Ptf1a gene
WebJul 7, 2015 · To explore the connection between PTF1A and pancreatic cancer, Krah et al. deleted the gene for PTF1A in mice. This led to acinar cells being reprogrammed to become ductal cells. Additionally, when an oncogene mutation was activated at the same time as the gene for PTF1A was deleted, Krah et al. observed the rapid formation of large numbers of ... WebJul 1, 2010 · In the adult cerebellum, atoh1a, atoh1b, and atoh1c are expressed in the molecular layer of the valvula cerebelli and of the medial corpus cerebelli, and ptf1a was detected in the VZ. The proneural gene expression patterns coincided with the sites of proliferating neuronal progenitors in the adult cerebellum.
Ptf1a gene
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WebMar 21, 2024 · PTF1A (Pancreas Associated Transcription Factor 1a) is a Protein Coding gene. Diseases associated with PTF1A include Pancreatic And Cerebellar Agenesis and Pancreatic Agenesis 2.Among its related pathways are Regulation of beta-cell … AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, … NANOG (Nanog Homeobox) is a Protein Coding gene. Diseases associated with … RBPJ (Recombination Signal Binding Protein For Immunoglobulin Kappa J … PDX1 (Pancreatic And Duodenal Homeobox 1) is a Protein Coding gene. Diseases … TRIP12 (Thyroid Hormone Receptor Interactor 12) is a Protein Coding gene. … TCF4 (Transcription Factor 4) is a Protein Coding gene. Diseases associated with … BMI1 (BMI1 Proto-Oncogene, Polycomb Ring Finger) is a Protein Coding gene. … KDM6A (Lysine Demethylase 6A) is a Protein Coding gene. Diseases … genecards suite products are for research use only, do not provide medical advice … Complete information for TCF24 gene (Protein Coding), Transcription Factor 24, … WebSep 1, 2008 · Ptf1a (PTF1-p48), a bHLH transcription factor, is indispensable for the formation of the exocrine pancreas and the correct spatial organization of the endocrine pancreas in mice ().Originally, Ptf1a was reported as a transcriptional regulator for acinar …
WebAug 7, 2024 · During this process, acinar cells change morphology, but also lose their secretory function and markedly alter their gene expression profile, progressively increasing the expression of duct-specific genes, and reducing the levels of genes encoding for acinar proteases ... (Ptf1a, Mist1, Gata6, and Rpbjl) ... WebPTF1A related diabetes is a form of monogenic neonatal diabetes caused by inherited a mutated copy of the PTF1A gene from both parents. This gene is important in the normal development of the brain and the …
WebApr 11, 2024 · The gene Ptf1a encodes a bHLH transcription factor protein that is a sequence-specific DNA-binding subunit of the trimeric pancreas transcription factor-1 [22]. Ptf1a was present in the earliest deuterostomes [21] and plays a role for the exocrine lineage of the pancreas as well as specific neuronal development [16], [17], [21]. WebMar 12, 2015 · Further reduction of ptf1a gene dosage converts pancreatic progenitor cells to gall bladder and other non-pancreatic cell fates. Conclusions : Our results confirm the presence of multipotent ptf1a -expressing progenitor cells in developing zebrafish pancreas, with reduced ptf1a dosage promoting greater contributions towards non-acinar lineages.
WebThese antibodies target PTF1A in Human, Rat and Mouse samples. Our PTF1A polyclonal, monoclonal, recombinant monoclonal and recombinant polyclonal antibodies are developed in Rabbit, Mouse and Goat. Find the PTF1A antibody that fits your needs. Choose from 1 …
WebAug 5, 2024 · See all available tests in GTR for this gene; Go to complete Gene record for PTF1A; Go to Variation Viewer for PTF1A variants; Summary. This gene encodes a protein that is a component of the pancreas transcription factor 1 complex (PTF1) and is known … number blocks one to a hundredWebThe gene view histogram is a graphical view of mutations across PTF1A. These mutations are displayed at the amino acid level across the full length of the gene by default. Restrict the view to a region of the gene by dragging across the histogram to highlight the region … numberblocks out of contextWebDescription: Homo sapiens pancreas associated transcription factor 1a (PTF1A), mRNA. (from RefSeq NM_178161) RefSeq Summary (NM_178161): This gene encodes a protein that is a component of the pancreas transcription factor 1 complex (PTF1) and is known … nintendo switch console trailerWebptf1a. Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Acts upstream of or within several processes, including amacrine cell differentiation; exocrine pancreas development; and positive regulation of DNA-templated … number blocks party invitationsWebFeb 21, 2013 · A. Strategy for disruption of the Gm13336-Ptf1a gene. The Gm13336-Ptf1a gene was disrupted using a targeting vector that contained a neomycin resistance (neo) gene flanked by loxP and lox2272. Exons of the Gm13336 and Ptf1a genes are shown as white and gray boxes, respectively. B. RT–PCR analyses of E9.5 embryos. number blocks online gamesWebThe death of Ptf1a-null mice soon after birth has not allowed further insight into the pathogenesis of the disease; it is therefore unclear how much pancreatic endocrine function is dependent on Ptf1a in mammals. This study aims to investigate gene-dosage effects of Ptf1a on pancreas development and function in mice. number blocks ordering numbers to 10WebRefSeq summary [PTF1A] This gene encodes a protein that is a component of the pancreas transcription factor 1 complex (PTF1) and is known to have a role in mammalian pancreatic development. The protein plays a role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal ... nintendo switch console smyths