WebConnective tissue growth factor is a growth factor with similar activities on collagen metabolism as TGF-β. It is a cysteine-rich peptide produced by fibroblasts and endothelial … WebLIG decreased the mRNA expression of TGF-β1, CTGF, monocyte chemoattractant protein-1 (MCP-1) and osteopontin, and, subsequently cytokeratin-18 expression decreased. Mainly, this molecule increased the expression of the natural inhibitors of TGF-β, hepatocyte growth factor (HGF) and bone morphogenetic protein (BMP)-7 ( Yuan et al., 2012 ) .
Frontiers Pivotal Role of TGF-β/Smad Signaling in Cardiac Fibrosis …
Web6 Jun 2012 · Transforming growth factor-beta (TGF-β), and downstream mediators including CTGF are major initiators of EMT processes in both fibrosis and cancer progression . These processes may be independent from each other as a TGF-β and CTGF-dependent induction of EMT was independent of the profibrotic effects of TGF-β in proximal tubular cells [ 18 ]. Web22 Jul 2002 · Because CTGF binds TGF-β1 with relatively low affinity (with a K D value of only 30 nM, Fig. 3f), it is conceivable that CTGF may function as a chaperone to modify … energy insight chanhassen mn
Curcumin relieves the arecoline-induced fibrosis of oral mucosal ...
Web6 Feb 2024 · Knockdown of Ctgf and Fgf-2 resulted in a lower Col1a1 expression level. Furthermore, the effects of TGF-β on myogenic and fibrotic gene expression were more … Web19 Apr 2024 · With the activation of TGF-β, Smad3/4 is recruited and combined with TGF-β to form a complex that translocates from the cytoplasm into the nucleus, leading to the transcription of fibrosis-related genes, such as α-SMA and Col-I. Additionally, many studies have confirmed that connective tissue growth factor (CTGF) plays the role of a modulator … Web23 Mar 2024 · CTGF seems to enhance the impact of TGF-β in the context of pro-inflammation [ 27 ]. It may act as a co-factor for TGF-β, but can also activate TGF-β in extracellular matrix signaling [ 28 ]. In pro-inflammatory lung injury, in concert with TGF-β, CTGF seems to trigger the production of remodeling molecules in the extracellular matrix … energy insights oilnow